FKBP4 antibody (AA 400-440)

Catalog No. ABIN7454750

This anti-FKBP4 antibody is a Rabbit Polyclonal antibody detecting FKBP4 in WB, IP and IHC (fp). Suitable for Human.

Quick Overview for FKBP4 antibody (AA 400-440) (ABIN7454750)

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-FKBP4 Antibody

Binding Specificity: AA 400-440

Purpose: Rabbit anti-FKBP4/FKBP52 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 400 and 440

Isotype: IgG

Application Details

Application Notes:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Alternative Name: FKBP4/FKBP52

Background: Background: FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.

Gene ID: 2288

NCBI Accession: NP_002005

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway