HEXIM1 antibody (AA 309-359)

Catalog No. ABIN7454896

The Rabbit Polyclonal anti-HEXIM1 antibody has been validated for WB, IP and IHC (fp). It is suitable to detect HEXIM1 in samples from Human and Mouse.

Quick Overview for HEXIM1 antibody (AA 309-359) (ABIN7454896)

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEXIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-HEXIM1 Antibody

Binding Specificity: AA 309-359

Purpose: Rabbit anti-HEXIM1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 309 and 359

Isotype: IgG

Application Details

Application Notes:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for HEXIM1

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Alternative Name: HEXIM1

Background: Background: Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM1sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity [taken from the Universal Protein Resource (UniProt) O94992].

Gene ID: 10614

NCBI Accession: NP_006451

UniProt: O94992