DYNC1I2 antibody (AA 588-638)

Catalog No. ABIN7455046

The Rabbit Polyclonal anti-DYNC1I2 antibody has been validated for WB, IHC (fp) and IP. It is suitable to detect DYNC1I2 in samples from Human and Mouse.

Quick Overview for DYNC1I2 antibody (AA 588-638) (ABIN7455046)

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC1I2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP)

Product Details anti-DYNC1I2 Antibody

Binding Specificity: AA 588-638

Purpose: Rabbit anti-DYNC1I2 Antibody, Affinity Purified

Predicted Reactivity: Rat,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: Between AA 588 and 638

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DYNC1I2

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Alternative Name: DYNC1I2

Background: Background: Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. DYNC1I2 is involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes [taken from the Universal Protein Resource (UniProt) Q13409].

Gene ID: 1781

NCBI Accession: NP_001369

UniProt: Q13409

Pathways: M Phase