MAVS antibody (AA 150-200)

Catalog No. ABIN7455082

The Rabbit Polyclonal anti-MAVS antibody has been validated for WB, IP, ICC and IHC (fp). It is suitable to detect MAVS in samples from Human.

Quick Overview for MAVS antibody (AA 150-200) (ABIN7455082)

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAVS antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-MAVS Antibody

Binding Specificity: AA 150-200

Purpose: Rabbit anti-MAVS/VISA Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 150 and 200

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

ICC: 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE cell sections.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MAVS

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Alternative Name: MAVS/VISA

Background: Background: Mitochondrial Antiviral-Signaling Protein (MAVS), also known as Virus-Induced Signaling Adaptor (VISA), is an adaptor protein that functions in the activation of the nuclear factor KappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) to mediate host innate immune responses against double-stranded RNA viral infection. MAVS (VISA) is localized to the outer mitochondrial membrane. Hepatitis C virus NS3/4A protease cleaves MAVS as part of an immune-evasion strategy.

Gene ID: 57506

UniProt: Q7Z434

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C