SIGLEC7 antibody

Catalog No. ABIN7490814

This anti-SIGLEC7 antibody is a Rabbit Chimeric antibody detecting SIGLEC7 in FACS. Suitable for Human.

Quick Overview for SIGLEC7 antibody (ABIN7490814)

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Fragment: Fc fragment

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This SIGLEC7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-SIGLEC7 Antibody

Characteristics: Rabbit/Human Fc chimeric IgG1

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for SIGLEC7

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Alternative Name: SIGLEC7

Background: AIRM-1, AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2,
Description: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34 cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB/Swiss-Prot Function]

UniProt: Q9Y286