Splicing factor U2AF 26 kDa subunit (U2AF1L4) antibody

Catalog No. ABIN7467804

This Rabbit Polyclonal antibody specifically detects in IF and ICC. It exhibits reactivity toward Human.

Quick Overview for Splicing factor U2AF 26 kDa subunit (U2AF1L4) antibody (ABIN7467804)

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human U2AF1L4. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details

Target: Splicing factor U2AF 26 kDa subunit (U2AF1L4)

Alternative Name: U2 small nuclear RNA auxiliary factor 1 like 4

Background: U2 small nuclear RNA auxiliary factor 1 like 4 , U2AF1-RS3 , U2AF1L3 , U2AF1L3V1 , U2AF1RS3 , U2af26,RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T cell activation, an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site.

Molecular Weight: 22 kDa

Gene ID: 199746

UniProt: Q8WU68