TPSAB1 antibody (AA 31-275)

Catalog No. ABIN7539786

This Mouse Monoclonal antibody specifically detects TPSAB1 in IHC, ELISA and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for TPSAB1 antibody (AA 31-275) (ABIN7539786)

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TPSAB1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 6B6B12

Product Details anti-TPSAB1 Antibody

Binding Specificity: AA 31-275

Purpose: TPSAB1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TPSAB1 (AA: 31-275) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TPSAB1

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Alternative Name: TPSAB1

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Molecular Weight: 30.5 kDa

Gene ID: 7177

UniProt: Q15661