TCR V Alpha24-J Alpha18 antibody
Reactivity: Human
FACS, ICC, IHC (fro)
Host: Mouse
Monoclonal
6B11
unconjugated
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- Target
- TCR V Alpha24-J Alpha18
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
- Application
- Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purpose
- Anti-Hu TCR Valpha24-Jalpha18 Purified
- Specificity
- The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT).
- Purification
- Purified by protein-A affinity chromatography.
- Clone
- 6B11
- Isotype
- IgG1 kappa
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- Application Notes
- Flow cytometry: Recommended dilution: 1-5 μg/mL
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- TCR V Alpha24-J Alpha18
- Alternative Name
- TCR Valpha24-Jalpha18
- Background
- TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT). This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer(support of both Th1 and Th2 way), although iNKT cells represent less than 1 % of total peripheral T cells.
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