TCR V Alpha24-J Alpha18 antibody

Catalog No. ABIN7540469

This Mouse Monoclonal antibody specifically detects in FACS, ICC and IHC (fro). It exhibits reactivity toward Human and Non-Human Primate.

Quick Overview for TCR V Alpha24-J Alpha18 antibody (ABIN7540469)

Target: TCR V Alpha24-J Alpha18

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 6B11

Product Details

Purpose: Anti-Hu TCR Valpha24-Jalpha18 Purified

Specificity: The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT).

Purification: Purified by protein-A affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-5 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details

Target: TCR V Alpha24-J Alpha18

Alternative Name: TCR Valpha24-Jalpha18

Background: TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT). This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer(support of both Th1 and Th2 way), although iNKT cells represent less than 1 % of total peripheral T cells.