FGF13 antibody (AA 2-18) (Biotin)

Catalog No. ABIN7540506

Supplier Product No.: 200-306-w62

The Mouse Monoclonal anti-FGF13 antibody has been validated for WB, IHC and ELISA. It is suitable to detect FGF13 in samples from Human.

Quick Overview for FGF13 antibody (AA 2-18) (Biotin) (ABIN7540506)

Target: FGF13 (Fibroblast Growth Factor 13 (FGF13))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGF13 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: S235-22

Product Details anti-FGF13 Antibody (Biotin)

Binding Specificity: AA 2-18

Supplier Product No.: 200-306-w62

Supplier: Rockland

Purpose: FGFA/FHFA (pan) Antibody Biotin

Cross-Reactivity (Details): BLAST analysis suggests that it is 94 % identical to mouse, 100 % identical to rat and >80 % identical to FGF12A/FHF1A, FGF14A/FHF4A, and FGF11A/FHF3A.

Purification: Anti-FGFA/FHFA (pan) Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: Anti-FGFA/FHFA (pan) Antibody was produced by repeated immunization of mice with a synthetic peptide containing amino acids 2-18 of human FHF2A.

Isotype: IgG2b

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Comment:

Anti-FGFA/FHFA (pan) Biotin Conjugated Antibody is tested for Western Blots, Immunohistochemistry and Immunocytochemistry. Expect a band approximately ~30 kDa on specific lysates or tissues. Does not cross react with FGF13B/FHF2B. Will cross react with FGF12A/FHF1A and FGF14A/FHF4A. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for FGF13

Target: FGF13 (Fibroblast Growth Factor 13 (FGF13))

Alternative Name: FGF13

Background: Acidic fibroblast growth factor, AFGF, Beta endothelial cell growth factor, Fibroblast growth factor homologous factor 2A, Fibroblast growth factor 13A, FGF13A, Beta-endothelial cell growth factor, ECGF, ECGFA antibody, ECGFB, FHF-2, FHF2, FHF13, Fibroblast growth factor homologous factor 2, Fibroblast growth factor 13,FGF13(Fibroblast growth factor 13), also called FHF2 is a protein that in humans is encoded by the FGF13 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF13is a large gene, extending over approximately 200 kb in Xq26.3, and contains at least 7 exons. By cytogenetic, FISH, and database analysis, Gecz et al. (1999) localized the FGF13 gene within a 400-kb duplication interval on chromosome Xq26.3. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. Other areas of interests and use for researchers include cancer, borjeson-forssman-lehmann syndrome, regulation of actin cytoskeleton pathways, apoptosis, GPCR pathways, TGF-Beta pathways, and Rho family GTPase pathways. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Gene ID: 2258

UniProt: Q92913

Pathways: Regulation of Cell Size