Recombinant CD172b / SIRP beta antibody

Catalog No. ABIN7543024

Product Details

Target: CD172b / SIRP beta

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), ELISA, Surface Plasmon Resonance (SPR)

Purpose: Anti-CD172b / SIRPB [OX-130], Rabbit IgG, kappa

Specificity: This antibody recognizes both common alleles of the human activating SIRPβ1 receptor, does not recognize SIRPγ, but cross-reacts with one of the common alleles of the inhibitory human SIRPα receptor.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogen: Recombinant SIRPbeta1 was purified by nickel affinity chromatography and used to immunize mice.

Clone: OX-130

Isotype: IgG kappa

Application Details

Application Notes: This antibody binds both common alleles of the human activating SIRPβ1 receptor, but ELISA and surface plasmon resonance results have shown that it reacts with one of the two common alleles of SIRPα, potentially yielding different outcomes when this antibody is used in assays from different individuals.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: CD172b / SIRP beta

Background: SIRP-beta-1, Signal-regulatory protein beta-1, CD172 antigen-like family member B

UniProt: O00241