Recombinant Desmocollin 2+3 (Extracellular Domain) antibody
Reactivity: Human
IF, FACS, IHC, IP
Host: Mouse
Monoclonal
7G6
unconjugated
Recombinant Antibody
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- Target
- Desmocollin 2+3
- Antibody Type
- Recombinant Antibody
- Binding Specificity
- Extracellular Domain
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
-
Application
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Purpose
- Anti-desmocollin-2/3 [7G6], Mouse IgG1, kappa
- Specificity
- This antibody recognizes desmocollin-2 (also known as Desmocollin-3). Desmocollins (next to desmogleins) are the main desmosomal transmembrane proteins.The expression of desmocollin-2 varies in the basal and suprabasal layers.
- Cross-Reactivity
- Mouse, Rat
- Characteristics
-
Original Species of Ab: Mouse
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- This antibody was raised by immunizing mice with a MBP-tagged recombinant protein corresponding to the extracellular domain of human Desmocollin-2.
- Clone
- 7G6
- Isotype
- IgG1 kappa
-
anti-Desmocollin 2+3 (Extracellular Domain) antibody
Reactivity: Human, Mouse, Rat IF, WB, FACS, IHC (p) Host: Mouse Monoclonal 7G6 unconjugated
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- Application Notes
- The antibody 7G6 is recommended for the detection and analysis of desmocollin-2 (desmocollin-3) via various methods, such as immunohistochemistry, Western blot and others. For instance, the antibody was used to label desmocollin-2 in primary human keratinocytes via immunohistochemistry (Franke et al., 2006). Similarly, another group detected desmocollin-2 in A431 cells (Wahl et al., 2005). The antibody 7G6 was also utilized in the assessment of expression levels of desmocollin-2 in SHEEC and KYSE510 cells via Western blot (Fang et al., 2014).
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
- Target
- Desmocollin 2+3
- Alternative Name
- desmocollin-2/3
- Background
- Desmocollin, Desmocollin-2, Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, Cadherin family member 3, Dsc2/3, Dsc2, Dsc3, DG2, DG3
- UniProt
- Q02487
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