CGRP antibody

Catalog No. ABIN7565819

The Mouse Monoclonal anti-CGRP antibody has been validated for ELISA and WB. It is suitable to detect CGRP in samples from Human.

Quick Overview for CGRP antibody (ABIN7565819)

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CGRP antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Clone: 8G10-H3-C3-G4-E2-C8

Product Details anti-CGRP Antibody

Purpose: Procalcitonin (8G10.H3.C3.G4.E2.C8) Antibody

Cross-Reactivity (Details): This antibody is specific for human Procalcitonin.

Characteristics: Synonyms: mouse anti-procalcitonin antibody, calcitonin isoform CT preproprotein, calcitonin-related polypeptide alpha, CT, KC, CGRP, CALC1, CGRP1, CGRP-I

Purification: Anti-Procalcitonin Antibody was purified from concentrated tissue culture supernate by Protein A chromatography.

Sterility: Sterile filtered

Immunogen:

Immunogen: Procalcitonin Antibody was produced in mice prepared by repeated immunizations with full-length recombinant human Procalcitonin protein.

Immunogen Type: Recombinant Protein

Isotype: IgG1 lambda

Application Details

Application Notes: Application Note: Anti-Procalcitonin [8G10.H3] antibody was tested by ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user. Western Blot Dilution: 1:1,000 - 1:2,000 ELISA Dilution: User Optimized Other: User Optimized

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for CGRP

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Alternative Name: CALCA

Background: Background: Anti-Procalcitonin antibody detects human Procalcitonin. Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, a N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour