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ACE2 antibody

This anti-ACE2 antibody is a Mouse Monoclonal antibody detecting ACE2 in WB, ELISA and Func. Suitable for Human.
Catalog No. ABIN7566405

Quick Overview for ACE2 antibody (ABIN7566405)

Target

See all ACE2 Antibodies
ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This ACE2 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Functional Studies (Func)

Clone

AC384
  • Purpose

    anti-ACE2 (human), mAb (blocking) (AC384) (preservative free)

    Characteristics

    Monoclonal Antibody. Recognizes human ACE2. Application: ELISA, WB, FUNC (Blocking). Clone: AC384. Isotype: Mouse IgG1κ. Liquid. In PBS. Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

    Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42 % sequence identity with ACE and its cytoplasmic and transmembrane domains show 48 % homology to the protein collectrin, that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

    Immunogen

    Recombinant human ACE2.

    Isotype

    IgG1 kappa
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    In PBS.

    Preservative

    Without preservative

    Handling Advice

    After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

    Storage

    4 °C,-20 °C

    Storage Comment

    +4°C

    Stable for at least 1 year after receipt when stored at -20°C.

  • Target

    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

    Alternative Name

    ACE2

    Pathways

    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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