CD276 antibody

Catalog No. ABIN7595384

This Mouse Monoclonal antibody specifically detects CD276 in ELISA, FACS and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CD276 antibody (ABIN7595384)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 7-517

Product Details anti-CD276 Antibody

Purpose: Anti-Hu CD276 Purified

Characteristics: The mouse monoclonal antibody 7-517 recognizes an extracellular epitope of human CD276 (B7H3) transmembrane glycoprotein.

Purification: Purified by protein-A affinity chromatography.

Immunogen: monocyte-derived dendritic cells

Isotype: IgG1, kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 0.5-4 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background: CD274 Molecule,CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its receptor CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.,B7H1, PDL1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7-H1

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints