DLG2 antibody (AA 1-852) (FL550)

Catalog No. ABIN7595549

This Mouse Monoclonal antibody specifically detects DLG2 in IHC and ICC. It exhibits reactivity toward Rat.

Quick Overview for DLG2 antibody (AA 1-852) (FL550) (ABIN7595549)

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This DLG2 antibody is conjugated to FL550

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N18-30

Product Details anti-DLG2 Antibody (FL550)

Binding Specificity: AA 1-852

Purpose: Anti-Chapsyn-110/PSD-93 Antibody FL550 Conjugate

Specificity: No off-targets reported for other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells

Cross-Reactivity: Human, Mouse, Rabbit, Rat

Characteristics:

Description: Our Anti-Chapsyn-110/PSD-93 mouse monoclonal primary antibody is produced in-house from hybridoma clone N18/30. It is KO validated, detects human, mouse, rabbit, and rat Chapsyn-110/PSD-93, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Chapsyn-110/PSD-93 mouse monoclonal primary antibody from hybridoma clone N18/30. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for DLG2

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Alternative Name: PSD-93

Background:

Synonyms: Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

Target Description: PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Gene Name Alternatives: Dlg2 Dlgh2

Molecular Weight: 110 kDa