NFASC antibody (Intracellular) (FL594)

Catalog No. ABIN7595781

The Mouse Monoclonal anti-NFASC antibody has been validated for IHC and ICC. It is suitable to detect NFASC in samples from Rat.

Quick Overview for NFASC antibody (Intracellular) (FL594) (ABIN7595781)

Target: NFASC (Neurofascin (NFASC))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NFASC antibody is conjugated to FL594

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: L11A-41

Product Details anti-NFASC Antibody (FL594)

Binding Specificity: Intracellular

Purpose: Anti-Pan-Neurofascin Antibody FL594 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Rat

Characteristics:

Description: Our Anti-Pan-Neurofascin mouse monoclonal primary antibody is produced in-house from hybridoma clone L11A/41. It detects human and rat Pan-Neurofascin, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Pan-Neurofascin mouse monoclonal primary antibody from hybridoma clone L11A/41. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein 1066-1174 (intracellular domain common to NF-155 and NF-186) of rat NF-155 (accession number AAL27854) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for NFASC

Target: NFASC (Neurofascin (NFASC))

Alternative Name: Neurofascin

Background:

Synonyms: Neurofascin NF-155 NF-186

Target Description: Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Gene Name Alternatives: Nfasc

Molecular Weight: 155, 186 kDa (plus additional bands on immunoblot)

Pathways: Cell-Cell Junction Organization