HCN4 antibody (AA 1019-1108) (FL650)

Catalog No. ABIN7595878

This anti-HCN4 antibody is a Mouse Monoclonal antibody detecting HCN4 in IHC and ICC. Suitable for Rat.

Quick Overview for HCN4 antibody (AA 1019-1108) (FL650) (ABIN7595878)

Target: HCN4 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HCN4 antibody is conjugated to FL650

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N114-10

Product Details anti-HCN4 Antibody (FL650)

Binding Specificity: AA 1019-1108

Purpose: Anti-HCN4 Antibody FL650 Conjugate

Specificity: No off-targets reported for other HCN's

Cross-Reactivity: Gerbil, Human, Mouse, Pig, Rat

Characteristics:

Description: Our Anti-HCN4 mouse monoclonal primary antibody is produced in-house from hybridoma clone N114/10. It detects human, mouse, and rat HCN4, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our HCN4 mouse monoclonal primary antibody from hybridoma clone N114/10. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (accession number Q9JKA7) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for HCN4

Target: HCN4 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4))

Alternative Name: HCN4

Background:

Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Target Description: HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.

Gene Name Alternatives: HCN4

Molecular Weight: 130 kDa