Msx2/Hox8 antibody (AA 1-129)

Catalog No. ABIN7598976

This Rabbit Polyclonal antibody specifically detects Msx2/Hox8 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for Msx2/Hox8 antibody (AA 1-129) (ABIN7598976)

Target: Msx2/Hox8 (Msx2) (Msh Momeobox 2 (Msx2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Msx2/Hox8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Msx2/Hox8 Antibody

Binding Specificity: AA 1-129

Purpose: Anti-Hox8/MSX2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Hox8/MSX2 Antibody Picoband® (ABIN7598976). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Hox8/MSX2 recombinant protein (Position: M1-M129).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bernardini, L., Castori, M., Capalbo, A., Mokini, V., Mingarelli, R., Simi, P., Bertuccelli, A., Novelli, A., Dallapiccola, B. Syndromic craniosynostosis due to complex chromosome 5 rearrangement and MSX2 gene triplication. Am. J. Med. Genet. 143A: 2937-2943, 2007. 2. Davidson, D. The function and evolution of Msx genes: pointers and paradoxes. Trends Genet. 11: 405-411, 1995. 3. Florisson, J. M. G., Verkerk, A. J. M. H., Huigh, D., Hoogeboom, A. J. M., Swagemakers, S., Kremer, A., Heijsman, D., Lequin, M. H., Mathijssen, I. M. J., van der Spek, P. J. Boston type craniosynostosis: report of a second mutation in MSX2. Am. J. Med. Genet. 161A: 2626-2633, 2013.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for Msx2/Hox8

Target: Msx2/Hox8 (Msx2) (Msh Momeobox 2 (Msx2))

Alternative Name: MSX2

Background:

Synonyms: Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Cholesterol-regulated 39 kDa protein, CR 39, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, Fdps

Tissue Specificity: Expressed ubiquitously.

Background: Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Molecular Weight: 37 kDa

Gene ID: 4488

UniProt: P35548