FERMT2 antibody (AA 1-650)

Catalog No. ABIN7599515

The Rabbit Polyclonal anti-FERMT2 antibody has been validated for WB, ELISA, IHC, IF, ICC and FACS. It is suitable to detect FERMT2 in samples from Human.

Quick Overview for FERMT2 antibody (AA 1-650) (ABIN7599515)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-FERMT2 Antibody

Binding Specificity: AA 1-650

Purpose: Anti-Kindlin 2/FERMT2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Kindlin 2/FERMT2 Antibody Picoband® (ABIN7599515). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Kindlin 2/FERMT2 recombinant protein (Position: M1-I650).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Rogalski, T. M., Mullen, G. P., Gilbert, M. M., Williams, B. D., Moerman, D. G. The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. J. Cell Biol. 150: 253-264, 2000. 2. Siegel, D. H., Ashton, G. H. S., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F. J. D., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., and 30 others. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am. J. Hum. Genet. 73: 174-187, 2003. 3. Tu, Y., Wu, S., Shi, X., Chen, K., Wu, C. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113: 37-47, 2003.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Alternative Name: FERMT2

Background:

Synonyms: DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46

Tissue Specificity: Ubiquitous.

Background: Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene. Enables several functions, including actin binding activity, phosphatidylinositol-3,4,5-trisphosphate binding activity, and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway, positive regulation of cell differentiation, and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol, focal adhesion, and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia.

Molecular Weight: 70 kDa

Gene ID: 10979

Pathways: Cell-Cell Junction Organization