GMP Synthase antibody (AA 21-671)

Catalog No. ABIN7600629

This Rabbit Polyclonal antibody specifically detects GMP Synthase in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GMP Synthase antibody (AA 21-671) (ABIN7600629)

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMP Synthase antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-GMP Synthase Antibody

Binding Specificity: AA 21-671

Purpose: Anti-GMPS Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-GMPS Antibody Picoband® (ABIN7600629). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GMPS recombinant protein (Position: H21-K671).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hirst, M., Haliday, E., Nakamura, J., Lou, L. Human GMP synthetase: protein purification, cloning, and functional expression of cDNA. J. Biol. Chem. 269: 23830-23837, 1994. 2. Pegram, L. D., Megonigal, M. D., Lange, B. J., Nowell, P. C., Rowley, J. D., Rappaport, E. F., Felix, C. A. t(3,11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5-prime monophosphate synthetase) gene. Blood 96: 4360-4362, 2000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for GMP Synthase

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Alternative Name: GMPS

Background:

Synonyms: DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46

Tissue Specificity: Ubiquitous.

Background: Guanosine monophosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.

Molecular Weight: 77 kDa

Gene ID: 8833

UniProt: P49915

Pathways: Ribonucleoside Biosynthetic Process