Innate Immunity Activator Protein (C1ORF106) (AA 236-663) antibody

Catalog No. ABIN7600790

This anti- antibody is a Rabbit Polyclonal antibody detecting in ELISA and WB. Suitable for Human.

Quick Overview for Innate Immunity Activator Protein (C1ORF106) (AA 236-663) antibody (ABIN7600790)

Target: Innate Immunity Activator Protein (C1ORF106)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 236-663

Purpose: Anti-INAVA Antibody Picoband®

Characteristics: Anti-INAVA Antibody Picoband® (ABIN7600790). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human INAVA recombinant protein (Position: Q236-V663). Human INAVA shares 85.3% amino acid (aa) sequence identity with mouse INAVA.

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Schumm, L. P., Sharma, Y., Anderson, C. A., Essers, J., Mitrovic, M., and 95 others. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491: 119-124, 2012. 2. Mohanan, V., Nakata, T., Desch, A. N., Levesque, C., Boroughs, A., Guzman, G., Cao, Z., Creasey, E., Yao, J., Boucher, G., Charron, G., Bhan, A. K., Schenone, M., Carr, S. A., Reinecker, H.-C., Daly, M. J., Rioux, J. D., Lassen, K. G., Xavier, R. J. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science 359: 1161-1166, 2018. 3. Rivas, M. A., Beaudoin, M., Gardet, A., Stevens, C., Sharma, Y., Zhang, C. K., Boucher, G., Ripke, S., Ellinghaus, D., Burtt, N., Fennell, T., Kirby, A., and 29 others. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nature Genet. 43: 1066-1073, 2011.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details

Target: Innate Immunity Activator Protein (C1ORF106)

Alternative Name: INAVA

Background: INAVA, sometimes referred to as hypothetical protein LOC55765, is a protein of unknown function that in humans is encoded by the INAVA gene. Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Molecular Weight: 70 kDa

Gene ID: 55765