RNASEL antibody (AA 24-735)

Catalog No. ABIN7600857

This Rabbit Polyclonal antibody specifically detects RNASEL in WB, ELISA and FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for RNASEL antibody (AA 24-735) (ABIN7600857)

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-RNASEL Antibody

Binding Specificity: AA 24-735

Purpose: Anti-RNase L/Rnasel Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-RNase L/Rnasel Antibody (ABIN7600857). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse RNase L/Rnasel recombinant protein (Position: E24-S735).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for RNASEL

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Alternative Name: Rnasel

Background:

Synonyms: Endothelin-converting enzyme 1,ECE-1,3.4.24.71,ECE1,

Tissue Specificity: All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma, isoforms A and C in liver, testis and small intestine, isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells, isoforms C and D in saphenous vein cells, and isoform C in kidney. .

Background: RNase L is an enzyme that in humans is encoded by the RNASEL gene. This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.

Molecular Weight: 83 kDa

Gene ID: 24014

UniProt: Q05921

Pathways: Hepatitis C