Secretin antibody (AA 25-65)

Catalog No. ABIN7600918

Product Details anti-Secretin Antibody

Target: Secretin (SECR)

Binding Specificity: AA 25-65

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Secretin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: Anti-Secretin/Sct Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Secretin/Sct Antibody Picoband® (ABIN7600918). Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Secretin/Sct recombinant protein (Position: A25-D65).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Bayliss, W., Starling, E. H. The mechanism of pancreatic secretion. J. Physiol. (London) 28: 325-353, 1902. 2. Chu, J. Y. S., Chung, S. C. K., Lam, A. K. M., Tam, S., Chung, S. K., Chow, B. K. C. Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Molec. Cell Biol. 27: 2499-2511, 2007. 3. Chu, J. Y. S., Lee, L. T. O., Lai, C. H., Vaudry, H., Chan, Y. S., Yung, W. H., Chow, B. K. C. Secretin as a neurohypophysial factor regulating body water homeostasis. Proc. Nat. Acad. Sci. 106: 15961-15966, 2009.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for Secretin

Target: Secretin (SECR)

Alternative Name: Sct (SECR Products)

Background:

Synonyms: Pannexin-2, PANX2

Tissue Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Background: Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene. This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone.

Molecular Weight: 70 kDa

Gene ID: 20287

UniProt: Q08535

Pathways: Stem Cell Maintenance