JDP2 antibody (AA 33-163)

Catalog No. ABIN7601338

The Rabbit Polyclonal anti-JDP2 antibody has been validated for WB and ELISA. It is suitable to detect JDP2 in samples from Human.

Quick Overview for JDP2 antibody (AA 33-163) (ABIN7601338)

Target: JDP2 (Jun Dimerization Protein 2 (JDP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JDP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-JDP2 Antibody

Binding Specificity: AA 33-163

Purpose: Anti-JDP2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-JDP2 Antibody Picoband® (ABIN7601338). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human JDP2 recombinant protein (Position: E33-K163).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Gross, M. B. Personal Communication. Baltimore, Md. 7/23/2013. 2. Heinrich, R., Livne, E., Ben-Izhak, O., Aronheim, A. The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene. J. Biol. Chem. 279: 5708-5715, 2004. 3. Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P., Doi, A., Lindau, P., Lee, H., Aryee, M. J., Irizarry, R. A., Kim, K., Rossi, D. J., Inlay, M. A., Serwold, T., Karsunky, H., Ho, L., Daley, G. Q., Weissman, I. L., Feinberg, A. P. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 467: 338-342, 2010.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for JDP2

Target: JDP2 (Jun Dimerization Protein 2 (JDP2))

Alternative Name: JDP2

Background:

Synonyms: Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2, RXFP2, GPR106, GREAT, LGR8

Tissue Specificity: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

Background: Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. Mouse Jdp2 is an inhibitory subunit of the differentiation regulatory factor (DRF) complex. Jdp2 repressed retinoic acid-induced transcription of the Jun gene by recruiting a histone deacetylase-3 -containing complex to the differentiation response element (DRE) of the Jun promoter. Expression of JDP2 was reduced in several human cancers compared with matched normal tissues. Human JDP2 has antitumorigenic properties.

Molecular Weight: 19 kDa

Gene ID: 122953

Pathways: Chromatin Binding