CD70 antibody (AA 36-191)

Catalog No. ABIN7601463

This Rabbit Polyclonal antibody specifically detects CD70 in WB, ELISA and IHC. It exhibits reactivity toward Mouse and Rat.

Quick Overview for CD70 antibody (AA 36-191) (ABIN7601463)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CD70 Antibody

Binding Specificity: AA 36-191

Purpose: Anti-Cd70 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Cd70 Antibody Picoband® (ABIN7601463). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Cd70 recombinant protein (Position: C36-Q191).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Abolhassani, H., Edwards, E. S. J., Ikinciogullari, A., Jing, H., Borte, S., Buggert, M., Du, L., Matsuda-Lennikov, M., Romano, R., Caridha, R., Bade, S., Zhang, Y., and 21 others. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J. Exp. Med. 214: 91-106, 2017. 2. Arens, R., Tesselaar, K., Baars, P. A., van Schijndel, G. M. W., Hendriks, J., Pals, S. T., Krimpenfort, P., Borst, J., van Oers, M. H. J., van Lier, R. A. W. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN-gamma-mediated B cell depletion. Immunity 15: 801-812, 2001. 3. Bowman, M. R., Crimmins, M. A. V., Yetz-Aldape, J., Kriz, R., Kelleher, K., Herrmann, S. The cloning of CD70 and its identification as the ligand for CD27. J. Immun. 152: 1756-1761, 1994.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: Cd70

Background:

Synonyms: gasdermin D, gasdermin-D

Tissue Specificity: Brain, placental, and gut tissues.

Background: CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Molecular Weight: 30 kDa

Gene ID: 21948

UniProt: O55237

Pathways: Cancer Immune Checkpoints