Cadherin 5 antibody (AA 48-272) (DyLight 488)

Catalog No. ABIN7601830

The Mouse Monoclonal anti-Cadherin 5 antibody has been validated for FACS. It is suitable to detect Cadherin 5 in samples from Human.

Quick Overview for Cadherin 5 antibody (AA 48-272) (DyLight 488) (ABIN7601830)

Target: Cadherin 5 (CDH5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cadherin 5 antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Clone: 3D4

Product Details anti-Cadherin 5 Antibody (DyLight 488)

Binding Specificity: AA 48-272

Purpose: Anti-Human VE-Cadherin CDH5 DyLight® 488 conjugated Antibody(monoclonal, 3D4)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human VE-Cadherin CDH5 DyLight® 488 conjugated Antibody (monoclonal, 3D4) (ABIN7606684)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: E. coli-derived human VE Cadherin recombinant protein (Position: D48-R272).

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, human
1. Huber, P., Dalmon, J., Engiles, J., Breviario, F., Gory, S., Siracusa, L. D., Buchberg, A. M., Dejana, E. Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 32: 21-28, 1996. 2. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: CDH5

Background:

Synonyms: Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5

Background: CDH5 (Cadherin 5), also known as VE-cadherin, is a type of cadherin. It is encoded by the human gene CDH5. This gene is mapped to 16q22.1 using somatic cell hybrid panels. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Therefore it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.

Molecular Weight: 39 kDa

Gene ID: 1003

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2