OTUD6B antibody (AA 66-293)

Catalog No. ABIN7602239

This anti-OTUD6B antibody is a Rabbit Polyclonal antibody detecting OTUD6B in WB, ELISA and FACS. Suitable for Human.

Quick Overview for OTUD6B antibody (AA 66-293) (ABIN7602239)

Target: OTUD6B (OTU Domain Containing 6B (OTUD6B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-OTUD6B Antibody

Binding Specificity: AA 66-293

Purpose: Anti-OTUD6B Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-OTUD6B Antibody Picoband® (ABIN7602239). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OTUD6B recombinant protein (Position: E66-S293). Human OTUD6B shares 87.8% amino acid (aa) sequence identity with mouse OTUD6B.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Kayagaki, N., Phung, Q., Chan, S., Chaudhari, R., Quan, C., O'Rourke, K. M., Eby, M., Pietras, E., Cheng, G., Bazan, J. F., Zhang, Z., Arnott, D., Dixit, V. M. DUBA: a deubiquitinase that regulates type I interferon production. Science 318: 1628-1632, 2007. 2. Santiago-Sim, T., Burrage, L. C., Ebstein, F., Tokita, M. J., Miller, M., Bi, W., Braxton, A. A., Rosenfeld, J. A., Shahrour, M., Lehmann, A., Cogne, B., Kury, S., and 33 others. Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features. Am. J. Hum. Genet. 100: 676-688, 2017. 3. Sobol, A., Askonas, C., Alani, S., Weber, M. J., Ananthanarayanan, V., Osipo, C., Bocchetta, M. Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation. Molec. Cancer Res. 15: 117-127, 2017.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for OTUD6B

Target: OTUD6B (OTU Domain Containing 6B (OTUD6B))

Alternative Name: OTUD6B

Background:

Synonyms: OTUD6B, DUBA5, CGI-77, Deubiquitinase OTUD6B, EC 3.4.19.12, DUBA-5, OTU domain-containing protein 6B

Background: OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene. This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells.

Molecular Weight: 36 kDa

Gene ID: 51633

UniProt: Q8N6M0