SCNM1 antibody (AA 8-230)

Catalog No. ABIN7602473

Product Details anti-SCNM1 Antibody

Target: SCNM1 (Sodium Channel Modifier 1 (SCNM1))

Binding Specificity: AA 8-230

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCNM1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: Anti-SCNM1 Antibody Picoband®

Characteristics: Anti-SCNM1 Antibody Picoband® (ABIN7602473). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SCNM1 recombinant protein (Position: D8-D230). Human SCNM1 shares 82.1% amino acid (aa) sequence identity with mouse SCNM1.

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Buchner, D. A., Trudeau, M., Meisler, M. H. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301: 967-969, 2003. 2. Howell, V. M., Jones, J. M., Bergren, S. K., Li, L., Billi, A. C., Avenarius, M. R., Meisler, M. H. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Molec. Genet. 16: 2506-2516, 2007. 3. Iturrate, A., Rivera-Barahona, A., Flores, C. L., Otaify, G. A., Elhossini, R., Perez-Sanz, M. L., Nevado, J., Tenorio-Castano, J., Trivino, J. C., Garcia-Gonzalo, F. R., Piceci-Sparascio, F., De Luca, A., Martinez, L., Kalayci, T., Lapunzina, P., Altunoglu, U., Aglan, M., Abdalla, E., Ruiz-Perez, V. L. Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia. Am. J. Hum. Genet. 109: 1828-1849, 2022.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for SCNM1

Target: SCNM1 (Sodium Channel Modifier 1 (SCNM1))

Alternative Name: SCNM1 (SCNM1 Products)

Background: SCNM1 is a zinc finger protein and putative splicing factor. In mice, Scnm1 modifies phenotypic expression of Scn8a (MIM 600702) mutations.

Molecular Weight: 26 kDa

Gene ID: 79005