COPE antibody (AA 80-308) (DyLight 488)

Catalog No. ABIN7602510

This Mouse Monoclonal antibody specifically detects COPE in FACS. It exhibits reactivity toward Human.

Quick Overview for COPE antibody (AA 80-308) (DyLight 488) (ABIN7602510)

Target: COPE (Coatomer Protein Complex, Subunit epsilon (COPE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COPE antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Clone: 9B6

Product Details anti-COPE Antibody (DyLight 488)

Binding Specificity: AA 80-308

Purpose: Anti-Human COPE DyLight® 488 conjugated Antibody(monoclonal, 9B6)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human COPE DyLight® 488 conjugated Antibody (monoclonal, 9B6) (ABIN7602509)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human COPE recombinant protein (Position: E80-A308). Human COPE shares 89.5% amino acid (aa) sequence identity with mouse COPE.

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human1. "Entrez Gene: COPE coatomer protein complex, subunit epsilon". 2. Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821-4.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: Lot specific

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for COPE

Target: COPE (Coatomer Protein Complex, Subunit epsilon (COPE))

Alternative Name: COPE

Background:

Synonyms: Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE

Tissue Specificity: Golgi apparatus membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, COPI-coated vesicle membrane, Peripheral membrane protein, Cytoplasmic side,

Background: Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene. The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 39 kDa

Gene ID: 11316

UniProt: O14579