DVL2 antibody (AA 89-576)

Catalog No. ABIN7602612

This Rabbit Polyclonal antibody specifically detects DVL2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DVL2 antibody (AA 89-576) (ABIN7602612)

Target: DVL2 (Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DVL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DVL2 Antibody

Binding Specificity: AA 89-576

Purpose: Anti-DVL2 Antibody Picoband®

Characteristics: Anti-DVL2 Antibody Picoband® (ABIN7602612). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DVL2 recombinant protein (Position: L89-Y576). Human DVL2 shares 97.3% amino acid (aa) sequence identity with mouse DVL2.

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., Overduin, M. The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature 419: 726-729, 2002. 2. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., Lefkowitz, R. J. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of frizzled 4. Science 301: 1391-1394, 2003. 3. Greco, T. L., Sussman, D. J., Camper, S. A. Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mammalian Genome 7: 475-476, 1996.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for DVL2

Target: DVL2 (Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2))

Alternative Name: DVL2

Background: Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40 % amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Molecular Weight: 85 kDa

Gene ID: 132299

UniProt: O14641

Pathways: Tube Formation