MAL antibody (C-Term)

Catalog No. ABIN7602807

This Rabbit Polyclonal antibody specifically detects MAL in WB. It exhibits reactivity toward Human.

Quick Overview for MAL antibody (C-Term) (ABIN7602807)

Target: MAL (Myelin and Lymphocyte Protein, T Cell Differentiation Protein (MAL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAL Antibody

Binding Specificity: C-Term

Purpose: Anti-MAL Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-MAL Antibody Picoband® (ABIN7602807). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MAL, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
1. Alonso, M., Barton, D. E., Francke, U. MAL, a membrane protein associated with human T-cell differentiation, is encoded on human chromosome 2, region cen-q13. (Abstract) Cytogenet. Cell Genet. 46: 570 only, 1987. 2. Alonso, M. A., Barton, D. E., Francke, U. Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen-q13. Immunogenetics 27: 91-95, 1988. 3. Alonso, M. A., Weissman, S. M. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. Proc. Nat. Acad. Sci. 84: 1997-2001, 1987.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.005 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for MAL

Target: MAL (Myelin and Lymphocyte Protein, T Cell Differentiation Protein (MAL))

Alternative Name: MAL

Background:

Synonyms: Semaphorin-3E, SEMA3E, KIAA0331, SEMAH

Tissue Specificity: Detected in the sinusoidal epithelium in the red pulp of spleen. Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Background: Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

Molecular Weight: 17 kDa

Gene ID: 4118

UniProt: P21145

Pathways: Asymmetric Protein Localization