HSD17B2 antibody (C-Term)

Catalog No. ABIN7602828

This Rabbit Polyclonal antibody specifically detects HSD17B2 in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for HSD17B2 antibody (C-Term) (ABIN7602828)

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-HSD17B2 Antibody

Binding Specificity: C-Term

Purpose: Anti-HSD17B2 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-HSD17B2 Antibody (ABIN7602828). Tested in Flow Cytometry, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for HSD17B2

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Alternative Name: HSD17B2

Background:

Synonyms: Tumor necrosis factor receptor superfamily member 4, MRC OX40, OX40 antigen, OX40L receptor, CD134, Tnfrsf4, Ox40, Txgp1l

Background: HSD17B2 (17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

Molecular Weight: 40 kDa

Gene ID: 3294

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis