SATB2 antibody (Middle Region)

Catalog No. ABIN7603086

This Rabbit Polyclonal antibody specifically detects SATB2 in WB. It exhibits reactivity toward Human.

Quick Overview for SATB2 antibody (Middle Region) (ABIN7603086)

Target: SATB2 (SATB Homeobox 2 (SATB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SATB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SATB2 Antibody

Binding Specificity: Middle Region

Purpose: Anti-SATB2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SATB2 Antibody Picoband® (ABIN7603086). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human SATB2, identical to the related mouse sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human
1. Bengani, H., Handley, M., Alvi, M., Ibitoye, R., Lees, M., Lynch, S. A., Lam, W., Fannemel, M., Nordgren, A., Malmgren, H., Kvarnung, M., Mehta, S., and 22 others. Clinical and molecular consequences of disease-associated de novo mutations in SATB2. Genet Med. 19: 900-908, 2017. 2. Brewer, C. M., Leek, J. P., Green, A. J., Holloway, S., Bonthron, D. T., Markham, A. F., FitzPatrick, D. R. A locus for isolated cleft palate, located on human chromosome 2q32. Am. J. Hum. Genet. 65: 387-396, 1999. 3. Britanova, O., Depew, M. J., Schwark, M., Thomas, B. L., Miletich, I., Sharpe, P., Tarabykin, V. Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am. J. Hum. Genet. 79: 668-678, 2006.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for SATB2

Target: SATB2 (SATB Homeobox 2 (SATB2))

Alternative Name: SATB2

Background:

Synonyms: Phospholipase D2, PLD 2, hPLD2, Choline phosphatase 2, PLD1C, Phosphatidylcholine-hydrolyzing phospholipase D2, PLD2

Tissue Specificity: Widely expressed.

Background: Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.

Molecular Weight: 90 kDa

Gene ID: 23314