Biglycan antibody (N-Term)

Catalog No. ABIN7603200

This Rabbit Polyclonal antibody specifically detects Biglycan in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Biglycan antibody (N-Term) (ABIN7603200)

Target: Biglycan (BGN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Biglycan antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Biglycan Antibody

Binding Specificity: N-Term

Purpose: Anti-Biglycan/BGN Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Biglycan/BGN Antibody Picoband® (ABIN7603200). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Biglycan/BGN, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Rat
1. Camera, G., Stella, G., Camera, A. New X linked spondyloepimetaphyseal dysplasia: report on eight affected males in the same family. J. Med. Genet. 31: 371-376, 1994. 2. Chatterjee, A., Faust, C. J., Herman, G. E. Genetic and physical mapping of the biglycan gene on the mouse X chromosome. Mammalian Genome 4: 33-36, 1993. 3. Cho, S. Y., Bae, J.-S., Kim, N. K. D., Forzano, F., Girisha, K. M., Baldo, C., Faravelli, F., Cho, T.-J., Kim, D., Lee, K. Y., Ikegawa, S., Shim, J. S., Ko, A.-R., Miyake, N., Nishimura, G., Superti-Furga, A., Spranger, J., Kim, O.-H., Park, W.-Y., Jin, D.-K. BGN mutations in X-linked spondyloepimetaphyseal dysplasia. Am. J. Hum. Genet. 98: 1243-1248, 2016.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for Biglycan

Target: Biglycan (BGN)

Alternative Name: BGN

Background:

Synonyms: BGN, SLRR1A, Biglycan, Bone/cartilage proteoglycan I, PG-S1

Background: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.

Molecular Weight: 48 kDa

Gene ID: 633

UniProt: P21810

Pathways: Glycosaminoglycan Metabolic Process