NAPB antibody (N-Term)

Catalog No. ABIN7603230

This Rabbit Polyclonal antibody specifically detects NAPB in WB. It exhibits reactivity toward Mouse and Rat.

Quick Overview for NAPB antibody (N-Term) (ABIN7603230)

Target: NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAPB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NAPB Antibody

Binding Specificity: N-Term

Purpose: Anti-NAPB Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-NAPB Antibody (ABIN7603230). Tested in WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminusof human NAPB, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for NAPB

Target: NAPB (N-Ethylmaleimide Sensitive Fusion Protein Attachment Protein beta (NAPB))

Alternative Name: NAPB

Background:

Synonyms: Tafazzin, Protein G4.5, TAZ, EFE2, G4.5

Tissue Specificity: High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

Background: Beta-soluble NSF attachment protein is a SNAP protein involved in vesicular trafficking and exocytosis which is encoded by the NAPB gene humans is. This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor.

Molecular Weight: 35 kDa

Gene ID: 63908

UniProt: Q9H115

Pathways: Synaptic Vesicle Exocytosis