PHOX2B antibody

Catalog No. ABIN7605939

This Rabbit Monoclonal antibody specifically detects PHOX2B in WB, IF, IHC and ICC. It exhibits reactivity toward Human and Mouse.

Quick Overview for PHOX2B antibody (ABIN7605939)

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PHOX2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: AEFG-16

Product Details anti-PHOX2B Antibody

Purpose: Anti-PHOX2B Monoclonal Antibody

Characteristics: Anti-PHOX2B Monoclonal Antibody (ABIN7605939). Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PHOX2B Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:100-1:500
ICC/IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for PHOX2B

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Alternative Name: PHOX2B

Background:

Synonyms: CD276 antigen,4Ig-B7-H3,B7 homolog 3,B7-H3,Costimulatory molecule,CD276,CD276,B7H3,PSEC0249, UNQ309/PRO352,

Tissue Specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. .

Molecular Weight: 90 kDa

UniProt: Q99453