CD6 antibody (CF®405S)

Catalog No. ABIN7651719

This anti-CD6 antibody is a Mouse Monoclonal antibody detecting CD6 in FACS, IF and Func. Suitable for Human and Mouse.

Quick Overview for CD6 antibody (CF®405S) (ABIN7651719)

Target: CD6

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD6 antibody is conjugated to CF®405S

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: SPV-L14

Product Details anti-CD6 Antibody (CF®405S)

Purpose: CD6 (Negative Marker of T-regulatory Cells)(SPV-L14), CF405S conjugate

Characteristics: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Immunogen: CD8 cytotoxic T-cell clone

Isotype: IgG1, kappa

Application Details

Application Notes: Flow cytometry: 1-2 μg/mL. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunofluorescence: 0.5-1 μg/mL. Optimal dilution for a specific application should be determined by user

Comment:

Positive Control: CCRF-CEM, Jurkat cells, Tonsil

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for CD6

Target: CD6

Alternative Name: CD6

Background:

Synonyms: T12, TP120

Gene Symbol: CD6

Tissue Expression: B-cells|T-cells

Molecular Weight: 90-130 kDa

Gene ID: 923

UniProt: P30203