Elastin antibody (CF®405S)

Catalog No. ABIN7653420

This anti-Elastin antibody is a Mouse Monoclonal antibody detecting Elastin in IHC and IHC (fp). Suitable for Human.

Quick Overview for Elastin antibody (CF®405S) (ABIN7653420)

Target: Elastin (ELN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Elastin antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: ELN-1981

Product Details anti-Elastin Antibody (CF®405S)

Purpose: Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) (ELN/1981), CF405S conjugate

Characteristics: Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries. It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticity to the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human Elastin protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Elastin

Target: Elastin (ELN)

Alternative Name: Elastin

Background:

Synonyms: Elastin, ELN, SVAS, Tropoelastin, WBS, WS

Gene Symbol: ELN

Molecular Weight: 70 kDa

Gene ID: 2006

UniProt: P15502

Pathways: Regulation of Actin Filament Polymerization