Recombinant TIMP2 antibody (N-Term)

Catalog No. ABIN7657008

This anti-TIMP2 antibody is a Mouse Monoclonal antibody detecting TIMP2 in IHC and IHC (fp). Suitable for Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Rabbit and Guinea Pig.

Quick Overview for Recombinant TIMP2 antibody (N-Term) (ABIN7657008)

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Rabbit, Guinea Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: RTIMP2-2335

Product Details anti-TIMP2 Antibody

Binding Specificity: AA 56-66, N-Term

Purpose: TIMP2 (Tissue Inhibitor of Metalloproteinase 2)(rTIMP2/2335)

Characteristics: Recognizes a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Preservative: Without preservative

Storage: -20 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Alternative Name: TIMP2

Background:

Synonyms: Metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP-2, TIMP2, Tissue Inhibitor of Metalloproteinase 2

Gene Symbol: TIMP2

Molecular Weight: 21 kDa

Gene ID: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process