Recombinant MALT1 antibody (AA 701-808)

Catalog No. ABIN7657499

The Rabbit Monoclonal anti-MALT1 antibody has been validated for IHC and IHC (fp). It is suitable to detect MALT1 in samples from Human.

Quick Overview for Recombinant MALT1 antibody (AA 701-808) (ABIN7657499)

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MALT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: MT1-3159R

Product Details anti-MALT1 Antibody

Binding Specificity: AA 701-808

Purpose: MALT1 (MALT-Lymphoma Marker)(MT1/3159R)

Characteristics: Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Human MALT1 recombinant fragment (aa701-808)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Jurkat, Daudi or HeLa cells. Tonsil or lymphoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS, 0.05 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Alternative Name: MALT1

Background:

Synonyms: Caspase-like protein, MALT lymphoma-associated translocation, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase

Gene Symbol: MALT1

Tissue Expression: B-cells

Molecular Weight: 93 kDa

Gene ID: 10892

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins