TGF-beta antibody (CF®405S)

Catalog No. ABIN7660686

This anti-TGF-beta antibody is a Mouse Monoclonal antibody detecting TGF-beta in . Suitable for Human, Mouse, Rat, Cow, Dog, Hamster and Monkey.

Quick Overview for TGF-beta antibody (CF®405S) (ABIN7660686)

Target: TGF-beta (TGFb)

Reactivity: Human, Mouse, Rat, Cow, Dog, Hamster, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGF-beta antibody is conjugated to CF®405S

Application: Please inquire

Clone: TGFB-510

Product Details anti-TGF-beta Antibody (CF®405S)

Purpose: TGF-beta (Transforming Growth Factor beta)(TGFB/510), CF405S conjugate

Characteristics: This MAb recognizes TGF beta 1, 2 and 3. TGFs inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Most breast lesions, benign and malignant, involve abnormal proliferation and altered architecture of stromal and/or epithelial elements.

Immunogen: Full length recombinant human TGF-beta2 protein

Isotype: IgG1, kappa

Application Details

Application Notes: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Comment:

Positive Control: Ovarian carcinoma, lung tumor or skin. PC-3 cell line. Eahy926 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for TGF-beta

Target: TGF-beta (TGFb)

Alternative Name: TGF-Beta

Background:

Synonyms: ARVD, BSC 1 cell growth inhibitor, CED, Cetermin, Diaphyseal dysplasia 1 (DPD1), Glioblastoma derived T cell suppressor factor (G TSF), Latency-associated peptide (LAP), Polyergin, Transforming growth factor beta 1 (TGF beta1 or TGFB1), TGF beta2 (TGFB2), TGF beta3 (TGFB3), TGFbeta (TGFB)

Gene Symbol: TFGB

Molecular Weight: ~13 kDa

Gene ID: 7040, 7042, 7043

UniProt: P01137, P10600, P61812

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus