Dapk1/2 (AA 271-370) antibody (Biotin)
Quick Overview for Dapk1/2 (AA 271-370) antibody (Biotin) (ABIN733360)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 271-370
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Cross-Reactivity
- Human, Mouse
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Predicted Reactivity
- Rat,Dog
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human DAPK2
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Isotype
- IgG
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anti-Dapk1/2 (AA 271-370) antibody
Reactivity: Human, Mouse WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
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Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C for 12 months.
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Expiry Date
- 12 months
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- Dapk1/2
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Background
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Synonyms: DRP1, DRP-1, Death-associated protein kinase 2, DAP kinase 2, DAP-kinase-related protein 1, DAPK2
Background: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
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Gene ID
- 23604
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UniProt
- Q9UIK4
Target
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