IGFBP3 antibody

Catalog No. ABIN7670640

The Mouse Monoclonal anti-IGFBP3 antibody has been validated for ELISA (Capture). It is suitable to detect IGFBP3 in samples from Human.

Quick Overview for IGFBP3 antibody (ABIN7670640)

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGFBP3 antibody is un-conjugated

Application: ELISA (Capture)

Clone: 13G2

Product Details anti-IGFBP3 Antibody

Purpose: IGFBP-3 Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Recombinant Human IGFBP-3 Protein expressed by Mammalian

Isotype: IgG1

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for IGFBP3

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Alternative Name: IGFBP-3

Background: InsuLin-Like growth factor-binding protein 3,IBP-3,IGF-binding protein 3,IGFBP-3,IGFBP3,IBP3,The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth,differentiation,and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory,apoptosis-inducing molecule,capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism,where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway,and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor,retinoid X receptor (RXR)-alpha,and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer,prostate cancer,colorectal cancer,and lung cancer. Moreover,IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.

UniProt: P17936

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding