OxLDL antibody

Catalog No. ABIN7670708

This Mouse Monoclonal antibody specifically detects OxLDL in ELISA (Detection). It exhibits reactivity toward Human.

Quick Overview for OxLDL antibody (ABIN7670708)

Target: OxLDL (Oxidized Low Density Lipoprotein (OxLDL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OxLDL antibody is un-conjugated

Application: ELISA (Detection)

Clone: 15F5

Product Details anti-OxLDL Antibody

Purpose: OxLDL Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Human OxLDL Native Protein

Isotype: IgG1

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for OxLDL

Target: OxLDL (Oxidized Low Density Lipoprotein (OxLDL))

Alternative Name: OxLDL

Background: Oxidized LDL,Ox LDL,Ox-LDL,Oxidized lDl (Ox-lDl) is a class of modified lDl. In addition to oxidation-modified lDl,modified lDl also includes acetylated lDl directly combined with malondialdehyde (MDA) and 4-hydroxylenic acid (4-HNE). These lDl which are not oxidation-modified but only chemically modified are called derived lDl. Different from derived lDl,Ox-lDl has unique physiological characteristics in the following aspects: (1) Ox-lDl can affect the metabolism of arachidonic acid and inhibit the esterification of cholesterol,but the derived lDl has no such effect,(2) Ox-lDl consumes endogenous antioxidant substances in lDl and reduces vitamin E content in lDl,while MDA-lDl has no such effect,(3) Oxidative modification involves lipid peroxidation,and PUFAs in lDl are oxidized,(4) When oxidized lDl is low in oxidation degree,ApoB degrades,When the oxidation degree is high,ApoB can be repolymerized. Ox-lDl is not metabolized by lDl receptors,and is recognized,bound,and endocytosed into cells by scavorator receptors. The normal cholesterol metabolism pathway is lost,resulting in intracellular lipid deposition and foam-like transformation.