PRTN3 antibody

Catalog No. ABIN7670731

This anti-PRTN3 antibody is a Rabbit Polyclonal antibody detecting PRTN3 in ELISA. Suitable for Human.

Quick Overview for PRTN3 antibody (ABIN7670731)

Target: PRTN3 (Proteinase 3 (PRTN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRTN3 antibody is un-conjugated

Application: ELISA

Product Details anti-PRTN3 Antibody

Purpose: Proteinase 3/PRTN3/PR3 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human Proteinase 3/PRTN3/PR3 protein expressed by Mammalian

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Alternative Name: Proteinase 3/PRTN3

Background: AGP,PRTN,proteinase,Leukocyte proteinase,Neutrophil proteinase,ACPA,AGP7,C-ANCA,CANCA,MBN,MBT,NP-4,NP4,P29,PR-3,PR3,PRTN3,proteinase 3,Myeloblastin,C-ANCA antigen,Leukocyte proteinase 3,Neutrophil proteinase 4,Wegener autoantigen,Proteinase 3 (PRTN3), also known as Myeloblastin (MBN), is a 32-33 kDa member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human PRTN3 proprecursor is 231 amino acids (aa) in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221 aa mature enzyme (aa 28-248), and an eight aa C?terminal propeptide (aa 249-256). Within the cell, a 35 kDa immature form exists, on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa 26-249, human PRTN3 shares 68 % aa identity with mouse PRTN3.

UniProt: P24158