RANKL antibody

Catalog No. ABIN7670758

This anti-RANKL antibody is a Mouse Monoclonal antibody detecting RANKL in ELISA. Suitable for Human.

Quick Overview for RANKL antibody (ABIN7670758)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RANKL antibody is un-conjugated

Application: ELISA

Clone: 4D4

Product Details anti-RANKL Antibody

Purpose: TRANCE/RANKL/TNFSF11 Monoclonal Antibody(Capture/Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Human TRANCE/RANKL/TNFSF11 protein expressed by E.coli

Isotype: IgG1

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Alternative Name: TRANCE/RANKL/TNFSF11

Background: CD254,TNFSF11,OPGL,RANKL,TRANCE,Tumor necrosis factor Ligand superfamiLy member 11,OsteocLast differentiation factor (ODF),Osteoprotegerin Ligand (OPGL),Receptor activator of nucLear factor kappa-B Ligand (RANKL),TNF-reLated activation-induced cytokine (TRANCE),Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells,chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1,which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

UniProt: O14788

Pathways: NF-kappaB Signaling