CCKBR antibody (AA 301-400)

Catalog No. ABIN734318

The Rabbit Polyclonal anti-CCKBR antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect CCKBR in samples from Mouse and Rat. There are 4+ publications available.

Quick Overview for CCKBR antibody (AA 301-400) (ABIN734318)

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCKBR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CCKBR Antibody

Binding Specificity: AA 301-400

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gastrin receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CCKBR antibody (ABIN734318)

Eberhard, Kirkeby, Hansen, Cayé-Thomasen: "Neurotransmitter and neurotransmitter receptor expression in the saccule of the human vestibular system." in: Progress in neurobiology, Vol. 212, pp. 102238, (2022) (PubMed).

Liu, Banerjee, Herring, Attalla, Hu, Xu, Shao, Simmons, Dadi, Wang, Jacobson, Liu, Hodges, Lau, Gu: "Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity." in: Developmental cell, Vol. 48, Issue 1, pp. 49-63.e7, (2019) (PubMed).

Mohammad, Ozaki, Takeuchi, Unno, Yamoto, Morioka, Takiguchi, Ikeda: "Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons." in: The Journal of biological chemistry, Vol. 287, Issue 47, pp. 39391-401, (2012) (PubMed).

Kalsheker, Hodgson, Watkins, White, Morrison, Stockley: "Deoxyribonucleic acid (DNA) polymorphism of the alpha 1-antitrypsin gene in chronic lung disease." in: British medical journal (Clinical research ed.), Vol. 294, Issue 6586, pp. 1511-4, (1987) (PubMed).

Target Details for CCKBR

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Alternative Name: Gastrin receptor/GASR/CCKBR

Background:

Synonyms: GASR, CCK-B, CCK2R, Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB

Background: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gene ID: 887

UniProt: P32239

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour