Prostaglandin E Synthase antibody (AA 85-152)

Catalog No. ABIN735788

The Rabbit Polyclonal anti-Prostaglandin E Synthase antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect Prostaglandin E Synthase in samples from Human.

Quick Overview for Prostaglandin E Synthase antibody (AA 85-152) (ABIN735788)

Target: Prostaglandin E Synthase (PTGES)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prostaglandin E Synthase antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Prostaglandin E Synthase Antibody

Binding Specificity: AA 85-152

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PTGEs

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Prostaglandin E Synthase

Target: Prostaglandin E Synthase (PTGES)

Alternative Name: PTGEs

Background:

Synonyms: PGES, MPGES, PIG12, PP102, PP1294, MGST-IV, MGST1L1, TP53I12, mPGES-1, MGST1-L1, Prostaglandin E synthase, Microsomal glutathione S-transferase 1-like 1, Microsomal prostaglandin E synthase 1, p53-induced gene 12 protein, PTGES, MPGES1

Background: Prostaglandin E synthase catalyses conversion of COX derived PGH2 to PGE2. It is a member of the MAPEG family. It may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain during inflammatory responses.The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Gene ID: 9536

UniProt: O14684