SLC6A4 antibody (AA 401-500)

Catalog No. ABIN735983

Product Details anti-SLC6A4 Antibody

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Binding Specificity: AA 401-500

Reactivity: Human, Rat, Mouse, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Chicken, Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5-HTT

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC6A4 antibody (ABIN735983)

Yu, Huang, Zhang, Ye, Chi, Zou, Lv, Zheng: "Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis." in: World journal of gastroenterology, Vol. 22, Issue 12, pp. 3451-9, (2016) (PubMed).

Wang, Gu, Liu, Bai, Wang: "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." in: Molecular medicine reports, Vol. 15, Issue 2, pp. 673-680, (2016) (PubMed).

Wojtal, Cee, Lang, Götze, Frühauf, Geier, Pastor-Anglada, Torres-Torronteras, Martí, Fried, Lutz, Maggiorini, Gassmann, Rogler, Vavricka: "Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 7, pp. G673-88, (2014) (PubMed).

Wang, Liu, Wang, Bai, Zhang, Sun, Wang: "Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats." in: Human & experimental toxicology, (2013) (PubMed).

Dong, Li, Zheng, Mu, Zhang, Liu: "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats." in: Journal of ethnopharmacology, Vol. 150, Issue 3, pp. 1053-61, (2013) (PubMed).

Bai, Wang, Liu, Wang, Lian, Zhang, Kang, Wang: "4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation." in: International journal of molecular medicine, Vol. 33, Issue 2, pp. 373-82, (2013) (PubMed).

Target Details for SLC6A4

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Alternative Name: SLC6A4/5-HTT (SLC6A4 Products)

Background:

Synonyms: HTT, 5HTT, OCD1, SERT, 5-HTT, SERT1, hSERT, 5-HTTLPR, Sodium-dependent serotonin transporter, 5HT transporter, Solute carrier family 6 member 4, SLC6A4

Background: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Gene ID: 6532

UniProt: P31645