Anthrax Toxin Lethal Factor antibody (Internal Region)

Catalog No. ABIN7794899

This Rabbit Polyclonal antibody specifically detects Anthrax Toxin Lethal Factor in . It exhibits reactivity toward Bacillus anthracis.

Quick Overview for Anthrax Toxin Lethal Factor antibody (Internal Region) (ABIN7794899)

Target: Anthrax Toxin Lethal Factor (Lef)

Reactivity: Bacillus anthracis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Anthrax Toxin Lethal Factor antibody is un-conjugated

Application: Please inquire

Product Details anti-Anthrax Toxin Lethal Factor Antibody

Binding Specificity: Internal Region

Purpose: Anti-Anthrax Lethal Factor (Intermediate Domain)

Specificity: Rabbit Anti-Anthrax Lethal Factor (Anthrax LF) recognizes an epitope in the intermediate domain of Anthrax LF. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Application Details

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/mL

Buffer: This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Target Details for Anthrax Toxin Lethal Factor

Target: Anthrax Toxin Lethal Factor (Lef)

Alternative Name: Anthrax Lethal Factor

Background: Anthrax Lethal Factor,